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Bee venom and SARS-CoV-2
NIH ^ | 4/30/2020 | Wei Yang, Fu-liang Hu, and Xiao-feng Xu

Posted on 17.5.2020, 18:22:48 by Gamecock

According to data from Johns Hopkins Coronavirus Resource Center, the global number of confirmed COVID-19 case exceeded 2.0 million on the 15th of April. I am a physician, and I participated the prevention and control of coronavirus in China.

There is one discovery we would like to report here. It reminds us the story of the discovery of cowpox and the eventual victory of humans over this disease (Bennett and Baxby, 1996). In Hubei province, the epicentre of COVID-19 in China, the local beekeepers association conducted a survey of beekeepers (Fig. 1 ). A total of 5115 beekeepers were surveyed from February 23 to March 8, including 723 in Wuhan, the outbreak epicentre of Hubei. None of these beekeepers developed symptoms associated with COVID-19, and their health was totally normal. After that, we interviewed five apitherapists in Wuhan and followed 121 patients of their apitherapy clinic. These patients had received apitherapy from October 2019 to December 2019, and all the five bee apitherapists have the habit of self-apitherapy for their own health care (apitherapy means making use of bee venom from the honeybee's sting to treat or prevent certain diseases). Without any protective measures, two of the five apitherapists were exposed to suspected COVID-19 cases and others were exposed to confirmed COVID-19 cases, but none of them were infected eventually. None of the 121 patients were infected by SARS-CoV-2, and three of them had close contact with immediate family members who were confirmed SARS-CoV-2 Infection cases. It might be supposed that beekeepers are less likely to be exposed to SARS-CoV-2 because they live in less densely populated rural areas. But the five apitherapists and their patients are from densely populated areas in Wuhan. These people have one thing in common: they develop a tolerance to bee sting.

Bee sting can cause allergic reactions (Park and Lee, 2016), and it can even lead to death due to the excessive stress response of the immune system (Vazquez-Revuelta and Madrigal-Burgaleta, 2018). Bee venom can affect the body's immune system (Cherniack and Govorushko, 2018) and enhance the differentiation of human regulatory T cells (Caramalho et al., 2015), which play an important role in control of SARS-CoV infection (Chen et al., 2010). Does the stimulation of the immune system caused by bee venom reduce susceptibility to SARS-CoV-2? To test this, animal experiments would be needed. Monkeys might be suitable for this study. Monkeys could be divided into two experimental groups with the same breed and age. One group could be made tolerant to bee venom after a period of daily bee stings, while the other group receives no intervention. They could then be raised in the same environment contaminated by SARS-CoV-2, and multiple tests performed to see if they were infected by SARS-CoV-2.

Our purpose in writing this letter is to ask scholars with appropriate research conditions to test this assumption. In the absence of vaccine of SARS-CoV-2, if this method works, then it could offer one hope towards victory over COVID-19.

Ethical statement The research conforms to moral and ethical norms. Project number of the funding: 0020190293.

Declaration of competing interest The authors have no conflicts of interest to declare. The survey data of beekeepers in Hubei province were provided by professor Fu-liang Hu, an expert of apiology. Dr. Xu gave me a lot of support on my task of the prevention and control of coronavirus.

TOPICS: Extended News
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1 posted on 17.5.2020, 18:22:48 by Gamecock
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To: Gamecock; Viking2002

Was telling Viking 2002 the other day about an old farmer from my childhood that would sting his hands with honeybee venom whenever they clawed up with severe arthritis.

The lowly honeybee. Pollinates food and flowers. Produces nature’s superfood, honey. And now this.

God loves us.

2 posted on 17.5.2020, 18:31:18 by Vigilantcitizen
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To: Vigilantcitizen

And honeybees are being killed off by murder hornets. Just one of many hazards of being a working bee. Bees are subject to a considerable number of infectious diseases and even the most innocuous applications of insecticides.

3 posted on 17.5.2020, 18:42:00 by alloysteel (Freedom is not a matter of life and death. It is much more serious than that..)
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To: Gamecock

My wife got bee venom injections 8 years ago for severe arthritis in her hands. Nothing else had worked.

She had about 6-7 injection sessions from a medical doctor. The itching was worse than the pain from the injections but she is still in very good condition.

4 posted on 17.5.2020, 18:42:44 by jcon40 (The other post before yours really nails it for me. IOr keep people from / PC ing in ver and alway)
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To: Gamecock

I used to keep a lot of bees. Getting occasionally is just a part of it. It always hurts, (I guess that’s why they call it a sting) but it is something one gets used to. Scrapping, not pulling the stinger out lessens the amount of venom one gets. The story always was that beekeepers rarely suffered from arthritis for whatever that’s worth.

The bee that stings you always pays with her life—she disembowels herself trying to pull the stinger out of you.

5 posted on 17.5.2020, 18:56:22 by hanamizu
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To: hanamizu

I have learned how not to get stung and have not been stung in 4 or 5 years. Maybe I should let them sting me once in a while.

6 posted on 17.5.2020, 19:00:27 by Meatspace
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To: Meatspace

My last have was particularly gentle and like you, I never got stung. I have found that bees and beekeeping forces calm on me. The bees aren’t impressed if I yell at them or swat at them. As you have learned, they have ways to let you know that they don’t want to be messed with on a particular day. Best to put it off until they’re in a better mood.

7 posted on 17.5.2020, 19:16:59 by hanamizu
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To: Gamecock
8 posted on 17.5.2020, 19:17:20 by moovova (Words are fun.)
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To: Gamecock
"But, but...President Trump told me to get bee stung!"

9 posted on 17.5.2020, 19:19:50 by moovova (Words are fun.)
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To: Gamecock

I had heard about the use for arthritis, but there may be some mechanism that boosts the immune system, or suppresses an inflammatory response.

Very much worth study.

10 posted on 17.5.2020, 19:32:05 by absalom01 (You should do your duty in all things. You cannot do more, and you should never wish to do less.)
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To: Gamecock
“Here! Let me inoculate you!”

Can Murder Hornets inoculate you, too?

11 posted on 17.5.2020, 19:39:04 by ProtectOurFreedom
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To: Gamecock
Beekeeping is an outdoors activity and outdoors is good against Covid because of UV light and vitamin D.
Did they take that into account?
12 posted on 17.5.2020, 20:34:15 by BitWielder1 (I'd rather have Unequal Wealth than Equal Poverty.)
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To: Vigilantcitizen

And honeybees help pollinate my fruit trees and berries. Wonderful little critters, and as long as you don’t bother them, they don’t bother you (as opposed to wasps and hornets).

13 posted on 17.5.2020, 23:38:40 by Viking2002 (Why should I walk into the great unknown, when I can sit here, and throw my bones?)
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